Chagas disease(CD) is a parasitic disease caused by Trypanosoma cruzi mainly transmitted by vectors like triatomines (ex. kissing bugs) ^13. This disease is endemic to Latin America, affecting 8-10 million people with an average of 41,200 new cases every year^7. However, the disease now has spread worldwide, affecting 300000-400000 people annually in non-endemic countries^5. This is because, many people from endemic regions migrate to non-endemic countries and some of them unknowingly have CD. To add to this, there are over 150 possible vectors all over the world and this disease has no functional vaccine. ^13. Therefore, a minor population carrying CD could easily spread the disease to a completely new population. Read More
The development of target specific drugs for treatment for different kinds of cancers has opened an entirely new avenue for alternative treatments that are safer and more efficient. Multiple clinical studies have revealed that in the case of fast-growing tumours like pancreatic neuroendocrine tumours (PNETs), target specific drugs such as Everolimus and Sunitinib have shown significantly positive results with maximum tumour shrinkage and minimal side-effects in comparison to existing conventional treatments.
The Purpose of Opinion:
Targeted Drug Therapy (TDT) can contribute to the development of a more cell-specific and faster-acting method of PNET suppression. A treatment personalized to different stages of cancer is much more efficient in comparison to treatments that focus on using the same protocol to destroy tumours irrespective of its proliferative stage. TDT brings in the question of whether it is time to pave a new path for these target specific drugs or hold on to existing standardized treatments such as non-target specific chemotherapy (CC- Conventional Chemotherapy) and radiation for PNETs.
PNETs are rare tumours that occur due to the rapid proliferation of certain hormone-making cells(islet cells) and stem cells of the pancreas. These tumours are a diverse cluster with varying clinical manifestations, tumour biology, and prognosis.
Millets comprise a family of warm-weather, annual cereals that have been grown for centuries worldwide, owing to their minimal soil requirements and high nutritious value. They are grainy and small in appearance; a trademark of many cereals showing little or no dependency on weather. This, combined with a relatively short growing season makes them an ideal drought crop. The pearl millet, commonly known as Bajra in many parts of India has been a staple dish for centuries whereas the finger millet, a sub family of millets called Ragi is extremely popular in South India. Read More